Introduction Mitral annular calcification (MAC) is a chronic degenerative process that affects the fibrous structure supporting the mitral valve. It is present in 8–15% of the general population; however, its prevalence can reach 40% in older people and 50% in patients with chronic kidney disease. Although it was previously classified as a degenerative pathophysiology associated with age or calcium metabolism, other etiological factors have been suggested, such as atherosclerotic disease and its risk factors (hypertension, obesity, dyslipidemia, diabetes mellitus, smoking), […]