Abstract Mitral regurgitation (MR) with multiple jets is a highly complex diagnostic scenario, frequently encountered in Barlow disease and functional phenotypes associated with ventricular remodeling. Conventional two-dimensional methods (e.g., vena contracta width, color jet area, and hemispheric proximal isovelocity surface area) have important limitations in the presence of multiple regurgitant orifices, eccentric jets, the Coanda effect, overlap of flow convergence zones, or noncircular annular geometry, which may lead to underestimation of volume overload. Three-dimensional echocardiography overcomes part of these limitations […]