Abstract Sickle cell disease (SCD) is the most prevalent hereditary genetic disorder worldwide, and cardiovascular alterations are the main cause of death among patients with this disease. Therefore, the early identification of markers of sickle cell cardiomyopathy using echocardiographic parameters (Central Illustration) is essential for the appropriate management of the cardiovascular condition in these patients. This review provides a comprehensive overview of the use of echocardiography in pediatric patients with SCD, highlighting the main characteristics of the condition and the […]

Abstract Sickle cell disease (SCD) is recognized as a global problem in public health, characterized by the alteration in the red blood cells to the sickle form. Moreover, chronic anemia can also be observed through the change in the rheology of the red blood cells, leading to a scenario of inflammation and oxidative stress, making SCD a multisystem disease. Cardiac output (CO) proved to be high, leading to an overall increase in the heart chambers and an eccentric myocardial hypertrophy. […]