Abstract Heart failure (HF) is a serious public health issue that impacts the mortality and morbidity of the global population. The prevalence of heart failure with preserved ejection fraction (HFpEF) is clearly increasing, associated with population aging, obesity, sedentary lifestyle, and cardiometabolic diseases. It is one of the most urgent diagnostic and therapeutic challenges nowadays. Additionally, the obesity phenotype of HFpEF may be associated with HF and occurs as a result of several mechanisms that are deleterious to cardiac function, […]