Abstract Background Dobutamine stress echocardiography (DSE) using the conventional protocol (CP-DSE) may lead to important adverse effects. Objective This study was aimed at assessing the safety of DSE using a modified protocol (MP-DSE). Methods Data were collected from our institutional database to compare MP-DSE with the CP-DSE. In the CP-DSE, atropine could be administered during the fourth stage or its extension. In the MP-DSE, atropine was initiated at the beginning of the third stage, and there was no stage extension. […]